SAR405838 is a highly selective MDM2 inhibitor that binds to MDM2 with a Ki value of 0.88 nM.

 

Brand: BCM

 

Solubility: Soluble in DMSO and Ethanol. Insoluble in water.

 

Isomeric SMILES: CC(C)(C)C[C@H]1[C@@]2([C@H]([C@@H](N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O  

 

InChIKey: IDKAKZRYYDCJDU-AEPXTFJPSA-N  

 

InChI: InChI=1S/C29H34Cl2FN3O3/c1-28(2,3)14-22-29(19-12-7-15(30)13-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-16-8-10-17(36)11-9-16/h4-7,12-13,16-17,22-23,25,35-36H,8-11,14H2,1-3H3,(H,33,37)(H,34,38)/t16?,17?,22-,23-,25+,29+/m0/s1

 

Attribute
[Chem Name]	MI-773
[CAS No.]	1303607-60-4
[Formula]	C₂₉H₃₄Cl₂FN₃O₃
[Molecular]	562.50
[Form]	Powder
[Storage]	Room temp
[Synonym]	(2'S,3R,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide; MI 77301

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