IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.

 

Brand: BCM

 

Signaling Pathways: DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Ubiquitination

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=CC(=C(N1C2=CC=C(C=C2)C#N)C)C(=O)CN3CCC(CC3)O  

 

InChIKey: WFOUOZGIXDMUJU-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H23N3O2/c1-14-11-19(20(25)13-22-9-7-18(24)8-10-22)15(2)23(14)17-5-3-16(12-21)4-6-17/h3-6,11,18,24H,7-10,13H2,1-2H3

 

Attribute
[Chem Name]	4-[3-[2-(4-hydroxypiperidin-1-yl)acetyl]-2,5-dimethylpyrrol-1-yl]benzonitrile
[Synonym]	Iu1-248
[CAS No.]	2307472-03-1
[MDL No.]	MFCD34469381
[Formula]	C20H23N3O2
[Molecular]	337.42
[Form]	Light brown to khaki solid
[Storage]	Powder: -20°C for 3 years. In solvent: -80°C for 2 years

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