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Jnk-in-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively, which can inhibit the phosphorylation of c-Jun, the direct substrate of JNK kinase.
Brand: BCM
Target: JNK
Signaling Pathways: MAPK
pKa: 13.34±0.70(Predicted)
Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.
GHS: GHS07
Isomeric SMILES: CN(C)C/C=C/C(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CN=CC=C4
InChIKey: RADRIIWGHYFWPP-WEVVVXLNSA-N
InChI: InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+
Attribute [Chem Name] 3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide [Synonym] JNK-IN-7; JNK inhibitor [CAS No.] 1408064-71-0 [MDL No.] MFCD25976765 [Formula] C28H27N7O2 [Molecular] 493.56 [Form] Solid [Storage] Keep in dark place. Sealed in dry. Room Temperature
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