Jnk-in-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor, which acts on JNK1, JNK2 and JNK3, with IC50 of 4.7 nM, 18.7 nM and 1 nM respectively IN A375 cell line, which is more than 10 times more selective than that for MNK2. There was no inhibitory effect on c-Kit, Met, PDGFRβ.

 

Brand: BCM

 

Target: c-Kit; JNK

 

Signaling Pathways: MAPK; Tyrosine Kinase/Adaptors

 

pKa: 13.34±0.70(Predicted)

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)/C=C/CN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4  

 

InChIKey: GJFCSAPFHAXMSF-UXBLZVDNSA-N  

 

InChI: InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ 

 

Attribute
[Chem Name]	3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
[Synonym]	JNK-IN-8; JNK Inhibitor XVI
[CAS No.]	1410880-22-6
[MDL No.]	MFCD22124890
[Formula]	C29H29N7O2
[Molecular]	507.59
[Form]	White to beige powder
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C

Goods Tag

JNK-IN-7

$45