RepSox (E-616452, SJN 2511, ALK5 Inhibitor II) is a potent and selective TGFβR-1/ALK5 inhibitor, which acts on ATP binding to ALK5 and ALK5 autophosphorylation with IC50 of 23 nM and 4 nM respectively in cell-free assay.

 

Brand: BCM

 

Melting Point: 195 °C

 

Boiling Point: 501.9±50.0 °C(Predicted)

 

pKa: 10.05±0.50(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4  

 

InChIKey: LBPKYPYHDKKRFS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

 

Attribute
[Chem Name]	2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
[Synonym]	RepSox; E-616452; SJN 2511; ALK5 Inhibitor II
[CAS No.]	446859-33-2
[MDL No.]	MFCD09037561
[Formula]	C17H13N5
[Molecular]	287.32
[Form]	Yellow solid
[Storage]	Sealed in dry, 2-8°C

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