FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 <5 μM. FLLL32 inhibits the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells.

 

Brand: BCM

 

Target: JAK; Apoptosis; STAT

 

Signaling Pathways: Angiogenesis; Stem Cells; Chromatin/Epigenetic; Apoptosis; JAK/STAT signaling

 

Solubility: Soluble in DMSO; soluble in Ethanol (warmed with 50ºC water bath). Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: COC1=C(C=C(C=C1)/C=C/C(=O)C2(CCCCC2)C(=O)/C=C/C3=CC(=C(C=C3)OC)OC)OC  

 

InChIKey: NQDROBVIYYEMDQ-WFYKWJGLSA-N  

 

InChI: InChI=1S/C28H32O6/c1-31-22-12-8-20(18-24(22)33-3)10-14-26(29)28(16-6-5-7-17-28)27(30)15-11-21-9-13-23(32-2)25(19-21)34-4/h8-15,18-19H,5-7,16-17H2,1-4H3/b14-10+,15-11+

 

Attribute
[Chem Name]	(E)-3-(3,4-dimethoxyphenyl)-1-[1-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]cyclohexyl]prop-2-en-1-one
[Synonym]	FLLL32; FLLL-32; FLLL 32
[CAS No.]	1226895-15-3
[MDL No.]	MFCD27976793
[Formula]	C28H32O6
[Molecular]	464.55008
[Form]	Crystalline solid
[Storage]	Inert atmosphere, 2-8°C

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