WZ811 is a highly potent, competitive CXCR4 antagonist with an EC50 of 0.3 nM.

 

Brand: BCM

 

Target: CXCR

 

Signaling Pathways: Autophagy; GPCR/G Protein; Immunology/Inflammation

 

In Vitro: WZ811 is a highly potent, competitive CXCR4 antagonist. WZ811 effectively counteracts the reduction of cAMP by SDF-1 at doses as low as a few nanomoles. WZ811 inhibits SDF-1-mediated invasion with an EC50 of 5.2 nM.

 

Melting Point: 192-194℃ (methanol)

 

Boiling Point: 493.2±35.0 °C(Predicted)

 

pKa: 6.55±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1=CC=NC(=C1)NCC2=CC=C(C=C2)CNC3=CC=CC=N3  

 

InChIKey: KBVFRXIGQQRMEF-UHFFFAOYSA-N  

 

InChI: InChI=1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)

 

Attribute
[Chem Name]	N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine
[CAS No.]	55778-02-4
[EINECS]	200-256-5
[MDL No.]	MFCD18086914
[Formula]	C18H18N4
[Molecular]	290.36
[Form]	White to tan powder
[Risk Codes]	H302-H315-H319-H335
[Storage]	Keep in dark place. Inert atmosphere.Store in freezer, under -20°C
[Synonym]	WZ-811; WZ811; WZ 811; N,N'-(1,4-Phenylenebis(methylene))bis(pyridin-2-amine)

Goods Tag