Bemcentinib (R428, BGB324) is an Axl inhibitor with an IC50 of 14 nM, and its action on Axl is more than 100 times more selective than that of Abl. Action on Axl is also more selective than for Mer and Tyro3(50 to 100 times higher) and InsR, EGFR, HER2, and PDGFRβ(100 times higher).

 

Brand: BCM

 

Target: TAM Receptor

 

Signaling Pathways: Tyrosine Kinase/Adaptors

 

Melting Point: >211°C (dec.)

 

Boiling Point: 799.6±70.0 °C(Predicted)

 

pKa: 10.34±0.20(Predicted)

 

Solubility: Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1CCN(C1)[C@H]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76  

 

InChIKey: KXMZDGSRSGHMMK-VWLOTQADSA-N  

 

InChI: InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1

 

Attribute
[Chem Name]	1-(3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine
[Synonym]	Bemcentinib; R428; BGB324
[CAS No.]	1037624-75-1
[MDL No.]	MFCD21608463
[Formula]	C30H34N8
[Molecular]	506.64
[Form]	Yellow powder.
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C

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