Axitinib is a multi-target inhibitor that acts on VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively, in pig aortic endothelial cells.

 

Brand: BCM

 

Target: VEGFR; c-Kit; PDGFR

 

Signaling Pathways: Angiogenesis; Tyrosine Kinase/Adaptors

 

Melting Point: 213-215°C

 

Boiling Point: 668.9±55.0 °C(Predicted)

 

pKa: 12.70±0.40(Predicted)

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07, GHS09

 

Isomeric SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4  

 

InChIKey: RITAVMQDGBJQJZ-FMIVXFBMSA-N  

 

InChI: InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

 

Attribute
[Chem Name]	N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
[Synonym]	Axitinib; AG 013736; AG013736
[CAS No.]	319460-85-0
[EINECS]	638-771-6
[MDL No.]	MFCD09837898
[Formula]	C22H18N4OS
[Molecular]	386.47
[Form]	White to tan powder
[Storage]	Sealed in dry, 2-8°C

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