BX-795 is a potent, specific inhibitor of PDK1, with an IC50 of 6 nM in cell-free trials and 140 and 1600 times higher selectivity against PDK1 than for PKA and PKC, respectively. At the same time, compared with GSK3β, the selectivity of action on PDK1 is more than 100 times higher. BX-795 regulates autophagy by inhibiting ULK1. BX-795 is also a potent TBK1 inhibitor, blocking TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.

 

Brand: BCM

 

Target: CDK; Autophagy; Chk; c-Kit; IκB/IKK; PDK

 

Signaling Pathways: Autophagy; Cell Cycle/Checkpoint; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors

 

Melting Point: >163°C (dec.)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethnaol.

 

Isomeric SMILES: C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I  

 

InChIKey: VAVXGGRQQJZYBL-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)

 

Attribute
[Chem Name]	N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
[Synonym]	BX-795
[CAS No.]	702675-74-9
[EINECS]	200-256-5
[MDL No.]	MFCD12546134
[Formula]	C23H26IN7O2S
[Molecular]	591.47
[Form]	White to light brown powder
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C

Goods Tag