Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of aryl hydrocarbon receptor (AhR) that induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with an EC50 value of 0.16 nM. Tapinarof can induce apoptosis in CD4+ T cells in a dose-dependent manner with an IC50 value of 5.2 μM.

 

Brand: BCM

 

Target: AhR; Aryl Hydrocarbon Receptor

 

Signaling Pathways: Immunology/Inflammation; Metabolism

 

Melting Point: 140 - 142°C

 

Boiling Point: 431.8±20.0 °C(Predicted)

 

pKa: 9.86±0.15(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC(C)C1=C(C=C(C=C1O)/C=C/C2=CC=CC=C2)O  

 

InChIKey: ZISJNXNHJRQYJO-CMDGGOBGSA-N  

 

InChI: InChI=1S/C17H18O2/c1-12(2)17-15(18)10-14(11-16(17)19)9-8-13-6-4-3-5-7-13/h3-12,18-19H,1-2H3/b9-8+

 

Attribute
[Chem Name]	5-[(E)-2-phenylethenyl]-2-propan-2-ylbenzene-1,3-diol
[Synonym]	Tapinarof; GSK2894512; Benvitimod; DHPS
[CAS No.]	79338-84-4
[EINECS]	1312995-182-4
[MDL No.]	MFCD13193203
[Formula]	C17H18O2
[Molecular]	254.32
[Form]	Pale Brown to Light Brown Solid
[Storage]	Sealed in dry, 2-8°C

Goods Tag