M3541 is a potent and selective inhibitor of ATM kinase activity with an IC50 value of 0.25 nM in cell-free assays. M3541 inhibits double-strand break (DSB) repair, clones cancer cell growth, and enhances anti-tumor activity of ionizing radiation in cancer cell lines.

 

Brand: BCM

 

Boiling Point: 634.8±65.0 °C(Predicted)

 

pKa: 5.36±0.20(Predicted)

 

Solubility: Solube in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CN1C=C(C=N1)C2=C(C=C3C(=C2)C4=C(C=N3)N(C(=O)N4C5=C(C=C(C=C5)C#N)F)C)OC  

 

InChIKey: OOCGUVCGJIUQKC-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H17FN6O2/c1-28-12-14(10-27-28)15-7-16-18(8-21(15)32-3)26-11-20-22(16)30(23(31)29(20)2)19-5-4-13(9-25)6-17(19)24/h4-8,10-12H,1-3H3

 

Attribute
[Chem Name]	3-fluoro-4-[7-methoxy-3-methyl-8-(1-methylpyrazol-4-yl)-2-oxoimidazo[4,5-c]quinolin-1-yl]benzonitrile
[Synonym]	M3541
[CAS No.]	1360628-91-6
[Formula]	C23H17FN6O2
[Molecular]	428.42
[Form]	Powder
[Storage]	Sealed in dry. Stored at -20°C.

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