BI-78D3 is a competitive JNK inhibitor with an IC50 of 280 nM, which is 100-fold more selective than p38α and has no activity against mTOR and PI-3K.

 

Brand: BCM

 

Target: JNK

 

Signaling Pathways: MAPK

 

In Vitro: BI-78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding and prevents JNK substrate phosphorylation.

 

In Vivo: In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes.

 

pKa: 2.76±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1COC2=C(O1)C=CC(=C2)N3C(=O)NN=C3SC4=NC=C(S4)[N+](=O)[O-]  

 

InChIKey: QFRLDZGQEZCCJZ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C13H9N5O5S2/c19-11-15-16-12(25-13-14-6-10(24-13)18(20)21)17(11)7-1-2-8-9(5-7)23-4-3-22-8/h1-2,5-6H,3-4H2,(H,15,19)

 

Attribute
[Chem Name]	4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-1,2,4-triazol-5-one
[Synonym]	BI-78D3
[CAS No.]	883065-90-5
[MDL No.]	MFCD01313575
[Formula]	C13H9N5O5S2
[Molecular]	379.37
[Form]	Solid Powder
[Storage]	Keep in dark place. Inert atmosphere. Store in freezer, under -20°C

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