Paprotrain, a cell permeability inhibitor of kinesin-MKLP-2, inhibited MKLP-2 atpase activity with an IC50 of 1.35 μM and a Ki of 3.36 μM, and showed moderate inhibitory activity against DYRK1A with an IC50 of 5.5 μM.

 

Brand: BCM

 

Target: Kinesin

 

Signaling Pathways: Cytoskeletal Signaling

 

Melting Point: 202℃

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1=CC=C2C(=C1)C(=CN2)/C(=C/C3=CN=CC=C3)/C#N  

 

InChIKey: YMYYQRZCCKBFBE-MDWZMJQESA-N  

 

InChI: InChI=1S/C16H11N3/c17-9-13(8-12-4-3-7-18-10-12)15-11-19-16-6-2-1-5-14(15)16/h1-8,10-11,19H/b13-8+ 

 

Attribute
[Chem Name]	(Z)-2-(1H-indol-3-yl)-3-pyridin-3-ylprop-2-enenitrile
[Synonym]	Paprotrain
[CAS No.]	57046-73-8
[MDL No.]	MFCD00617529
[Formula]	C16H11N3
[Molecular]	245.28
[Form]	Powder
[Storage]	Sealed in dry, 2-8°C

Goods Tag